High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
Identifieur interne : 000229 ( Main/Exploration ); précédent : 000228; suivant : 000230High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
Auteurs : Jinpan Liu [République populaire de Chine] ; Ronghui Li [République populaire de Chine] ; Tongjun Liu [République populaire de Chine] ; Xiaohui Rausch-Fan [Autriche] ; Mingguo Wang [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.
Url:
DOI: 10.1038/s41598-017-06937-y
PubMed: 28765610
PubMed Central: 5539157
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author><author><name sortKey="Li, Ronghui" sort="Li, Ronghui" uniqKey="Li R" first="Ronghui" last="Li">Ronghui Li</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 1174</institution-id><institution-id institution-id-type="GRID">grid.27255.37</institution-id><institution>Department of Stomatology, Jinan Central Hospital,</institution><institution>Shandong University,</institution></institution-wrap>Jinan, 250013 P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Tongjun" sort="Liu, Tongjun" uniqKey="Liu T" first="Tongjun" last="Liu">Tongjun Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 1174</institution-id><institution-id institution-id-type="GRID">grid.27255.37</institution-id><institution>Department of Stomatology, Jinan Central Hospital,</institution><institution>Shandong University,</institution></institution-wrap>Jinan, 250013 P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author><author><name sortKey="Rausch Fan, Xiaohui" sort="Rausch Fan, Xiaohui" uniqKey="Rausch Fan X" first="Xiaohui" last="Rausch-Fan">Xiaohui Rausch-Fan</name><affiliation wicri:level="3"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9259 8492</institution-id><institution-id institution-id-type="GRID">grid.22937.3d</institution-id><institution>Division of Conservative Dentistry and Periodontology,</institution><institution>School of Dentistry, Medical University of Vienna,</institution></institution-wrap>Sensengasse 2a, 1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Sensengasse 2a, 1090 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Wang, Mingguo" sort="Wang, Mingguo" uniqKey="Wang M" first="Mingguo" last="Wang">Mingguo Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 1174</institution-id><institution-id institution-id-type="GRID">grid.27255.37</institution-id><institution>Department of Stomatology, Jinan Central Hospital,</institution><institution>Shandong University,</institution></institution-wrap>Jinan, 250013 P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kuula, H" uniqKey="Kuula H">H Kuula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author><author><name sortKey="Meyle, J" uniqKey="Meyle J">J Meyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abrahamsson, I" uniqKey="Abrahamsson I">I Abrahamsson</name></author><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T Berglundh</name></author><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liskmann, S" uniqKey="Liskmann S">S 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Popovic</name></author><author><name sortKey="Harris, He" uniqKey="Harris H">HE Harris</name></author><author><name sortKey="Naucler, Cs" uniqKey="Naucler C">CS Naucler</name></author><author><name sortKey="Wahren Herlenius, M" uniqKey="Wahren Herlenius M">M Wahren-Herlenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gemmell, E" uniqKey="Gemmell E">E Gemmell</name></author><author><name sortKey="Carter, Cl" uniqKey="Carter C">CL Carter</name></author><author><name sortKey="Seymour, Gj" uniqKey="Seymour G">GJ Seymour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hasegawa, N" uniqKey="Hasegawa N">N Hasegawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agnello, D" uniqKey="Agnello D">D Agnello</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Tracey, Kj" uniqKey="Tracey K">KJ Tracey</name></author><author><name sortKey="Ghezzi, P" uniqKey="Ghezzi P">P Ghezzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Jh" uniqKey="Liu J">JH Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Autriche</li><li>République populaire de Chine</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Jinpan" sort="Liu, Jinpan" uniqKey="Liu J" first="Jinpan" last="Liu">Jinpan Liu</name></noRegion><name sortKey="Li, Ronghui" sort="Li, Ronghui" uniqKey="Li R" first="Ronghui" last="Li">Ronghui Li</name><name sortKey="Liu, Tongjun" sort="Liu, Tongjun" uniqKey="Liu T" first="Tongjun" last="Liu">Tongjun Liu</name><name sortKey="Wang, Mingguo" sort="Wang, Mingguo" uniqKey="Wang M" first="Mingguo" last="Wang">Mingguo Wang</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Rausch Fan, Xiaohui" sort="Rausch Fan, Xiaohui" uniqKey="Rausch Fan X" first="Xiaohui" last="Rausch-Fan">Xiaohui Rausch-Fan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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